Publications

M. Amatruda, D. Marechal, M. Gacias, M. Wentling, S. Turpin‐Nolan, J. Morstein, M. Moniruzzaman, J. C. Brüning, N. J. Haughey, D. H. Trauner, P. Casaccia. Neuroprotective Effect of Neuron‐specific Deletion of the C16 Ceramide Synthetic Enzymes in an Animal Model of Multiple Sclerosis. Glia, 2024, glia.24631. DOI: https://doi.org/10.1002/glia.24631.

S. B. Siems, V. Gargareta, L. C. Schadt, V. Daguano Gastaldi, R. B. Jung, L. Piepkorn, P. Casaccia, T. Sun, O. Jahn, H. B. Werner. Developmental Maturation and Regional Heterogeneity but No Sexual Dimorphism of the Murine CNS Myelin Proteome. Glia, 2024, glia.24614. DOI: https://doi.org/10.1002/glia.24614.

D. Huang, A. Mela, N. V. Bhanu, B. A. Garcia, P. Canoll, P. Casaccia. PDGF-BB Overexpression in P53 Null Oligodendrocyte Progenitors Increases H3K27me3 and Induces Transcriptional Changes Which Favor Proliferation. Neoplasia, 2024, 57, 101042. DOI: https://doi.org/10.1016/j.neo.2024.101042.

B. L. L. Clayton, L. Barbar, M. Sapar, K. Kalpana, C. Rao, B. Migliori, T. Rusielewicz, D. Paull, K. Brenner, D. Moroziewicz, I. K. Sand, P. Casaccia, P. J. Tesar, V. Fossati. Patient iPSC Models Reveal Glia-Intrinsic Phenotypes in Multiple Sclerosis. Cell Stem Cell, 2024, S1934590924002881. DOI: https://doi.org/10.1016/j.stem.2024.08.002.

Kim JW, Yong AJH, Aisenberg EE, Lobel JH, Wang W, Dawson TM, et al. Molecular recording of calcium signals via calcium-dependent proximity labeling. Nat Chem Biol. 2024;20:894–905. doi:10.1038/s41589-024-01603-7 PubMed PMID: 38658655.

P. Deshpande, E. Prentice, A. V. Ceballos, P. Casaccia, S. Elbaum-Garfinkle. Epigenetic Marks Uniquely Tune the Material Properties of HP1α Condensates. Biophysical Journal, 2024, S0006349524002820.

Yijing Zhou, Vanessa B. Sanchez, Peining Xu, Thomas Roule, Marco Flores-Mendez, Brianna, Ciesielski4, Donna Yoo, Hiab Teshome, Teresa Jimenez, Shibo Liu, Mike Henne, Tim O’Brien, Ye He, Clementina Mesaros, Naiara Akizu. Altered lipid homeostasis is associated with cerebellar neurodegeneration in SNX14 deficiency. JCI Insights, 2024 Apr 16;9(10):e168594. PMID: 38625743

N. Nayeem, S. Sauma, A. Ahad, R. Rameau, S. Kebadze, M. Bazett, B. J. Park, P. Casaccia, S. Prabha, K. Hubbard, M. Contel. Insights into Mechanisms and Promising Triple Negative Breast Cancer Therapeutic Potential for a Water-Soluble Ruthenium Compound. ACS Pharmacol. Transl. Sci., 2024, acsptsci.4c00020. DOI: https://doi.org/10.1021/acsptsci.4c00020.

A. Flury, L. Aljayousi, S. Aziz, H.-J. Park, M. Khakpour, C. Sandberg, F. G. Ibáñez, O. Braniff, P. Deme, J. D. McGrath, T. Ngo, J. Mechler, D. M. Ramirez, D. Avnon-Klein, J. W. Murray, J. Liu, N. J. Haughey, S. Werneburg, M.-È. Tremblay, P. Ayata. Integrated Stress Response Associated with Dark Microglia Promotes Microglial Lipogenesis and Contributes to Neurodegeneration. preprint. bioRxiv 2024.03.04.582965; doi: https://doi.org/10.1101/2024.03.04.582965

L. Sprinzen, F. Garcia, A. Mela, L. Lei, P. Upadhyayula, A. Mahajan, N. Humala, L. Manier, R. Caprioli, A. Quiñones-Hinojosa, P. Casaccia, P. Canoll. EZH2 Inhibition Sensitizes IDH1R132H-Mutant Gliomas to Histone Deacetylase Inhibitor. Cells, 2024, 13 (3), 219. DOI: https://doi.org/10.3390/cells13030219.

M. Caldwell, V. Ayo-Jibunoh, J. C. Mendoza, K. R. Brimblecombe, L. M. Reynolds, X. Y. Zhu Jiang, C. Alarcon, E. Fiore, J. N. Tomaio, G. R. Phillips, S. Mingote, C. Flores, P. Casaccia, J. Liu, S. J. Cragg, D. P. McCloskey, L. Yetnikoff. Axo-Glial Interactions between Midbrain Dopamine Neurons and Oligodendrocyte Lineage Cells in the Anterior Corpus Callosum. Brain Struct Funct, 2023. DOI: https://doi.org/10.1007/s00429-023-02695-y.

W. T. Ralvenius, A. E. Mungenast, H. Woolf, M. M. Huston, T. Z. Gillingham, S. K. Godin, J. Penney, H. P. Cam, F. Gao, C. G. Fernandez, B. Czako, Y. Lightfoot, W. J. Ray, A. Beckmann, A. M. Goate, E. Marcora, C. Romero-Molina, P. Ayata, A. Schaefer, E. Gjoneska, et al. A Novel Molecular Class That Recruits HDAC/MECP2 Complexes to PU.1 Motifs Reduces Neuroinflammation. Journal of Experimental Medicine, 2023, 220 (11), e20222105. DOI: https://doi.org/10.1084/jem.20222105.

I. Kadam, M. Dalloul, J. Hausser, M. Huntley, L. Hoepner, L. Fordjour, J. Hittelman, A. Saxena, J. Liu, I. D. Futterman, H. Minkoff, X. Jiang. Associations between Nutrients in One-Carbon Metabolism and Fetal DNA Methylation in Pregnancies with or without Gestational Diabetes Mellitus. Clin Epigenet, 2023, 15 (1), 137. DOI: https://doi.org/10.1186/s13148-023-01554-1.

R. Ravenelle, C. Fernandes-Henriques, J. Lee, J. Liu, E. Likhtik, N. S. Burghardt. Serotonergic Modulation of the BNST-CeA Circuit Promotes Sex Differences in Fear Learning. preprint. bioRxiv, 2023. DOI: https://doi.org/10.1101/2023.07.03.547577.

A. Obenaus, E. Kinney-Lang, A. Jullienne, E. Haddad, K. M. Wendel, A. D. Shereen, A. Solodkin, J. F. Dunn, T. Z. Baram. Seeking the Amygdala: Novel Use of Diffusion Tensor Imaging to Delineate the Basolateral Amygdala. Biomedicines, 2023, 11 (2), 535. DOI: https://doi.org/10.3390/biomedicines11020535.

I. Selcen, E. Prentice, P. Casaccia. The Epigenetic Landscape of Oligodendrocyte Lineage Cells. Ann N Y Acad Sci, 2023. DOI: https://doi.org/10.1111/nyas.14959.

G. M. Demirci, D. Delngeniis, W. M. Wong, A. D. Shereen, Y. Nomura, C.-L. Tsai. Superstorm Sandy Exposure in Utero Is Associated with Neurobehavioral Phenotypes and Brain Structure Alterations in Childhood: A Machine Learning Approach. Front. Neurosci., 2023, 17, 1113927. DOI: https://doi.org/10.3389/fnins.2023.1113927.

G. Hsu, A. D. Shereen, L. G. Cohen, L. C. Parra. Robust Enhancement of Motor Sequence Learning with 4 MA Transcranial Electric Stimulation. Brain Stimulation, 2023, 16 (1), 56–67. DOI: https://doi.org/10.1016/j.brs.2022.12.011.

X. Chen, A. Momin, S. Wanggou, X. Wang, H.-K. Min, W. Dou, Z. Gong, J. Chan, W. Dong, J. J. Fan, Y. Xiong, K. Talipova, H. Zhao, Y. X. Chen, K. Veerasammy, A. Fekete, S. A. Kumar, H. Liu, Q. Yang, J. E. Son, et al. Mechanosensitive Brain Tumor Cells Construct Blood-Tumor Barrier to Mask Chemosensitivity. Neuron, 2022. DOI: https://doi.org/10.1016/j.neuron.2022.10.007.

B. Mulyana, A. Tsuchiyagaito, M. Misaki, R. Kuplicki, J. Smith, G. Soleimani, A. Rashedi, D. Shereen, T. O. Bergman, S. Cheng, M. P. Paulus, J. Bodurka, H. Ekhtiari. Online Closed‐loop Real‐time TES‐fMRI for Brain Modulation: A Technical Report. Brain and Behavior, 2022, 12 (10), e2667. DOI: https://doi.org/10.1002/brb3.2667.

G. A. Soliman, R. R. Abzalimov, Y. He. MTORC1 and MTORC2 Complexes Regulate the Untargeted Metabolomics and Amino Acid Metabolites Profile through Mitochondrial Bioenergetic Functions in Pancreatic Beta Cells. Nutrients, 2022, 14 (15), 3022. DOI: https://doi.org/10.3390/nu14153022.

Y. X. Chen, K. Veerasammy, J. Yin, T. Choetso, T. Zhong, M. A. Choudhury, C. Weng, E. Xu, M. A. Hein, R. Abzalimov, Y. He. Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. JoVE (Journal of Visualized Experiments), 2022, No. 185, e63930. DOI: https://doi.org/10.3791/63930.

J. Buthmann, D. Huang, P. Casaccia, S. O’Neill, Y. Nomura, J. Liu. Prenatal Exposure to a Climate-Related Disaster Results in Changes of the Placental Transcriptome and Infant Temperament. Frontiers in Genetics, 2022, 13.

H.-J. Park, E. Tsai, D. Huang, M. Weaver, L. Frick, A. Alcantara, J. J. Moran, J. Patzig, C. V. Melendez-Vasquez, G. R. Crabtree, M. L. Feltri, J. Svaren, P. Casaccia. ACTL6a Coordinates Axonal Caliber Recognition and Myelination in the Peripheral Nerve. iScience, 2022, 25 (4), 104132. DOI: https://doi.org/10.1016/j.isci.2022.104132.

Nomura Y, Kittler P, Taveras S, et al. Psychological Effects of COVID-19 on Pregnant Women and New Mothers Living in a US Hotspot. J Gynec Obstet 2022; 5:038.

F. Cathomas, L. M. Holt, E. M. Parise, J. Liu, J. W. Murrough, P. Casaccia, E. J. Nestler, S. J. Russo. Beyond the Neuron: Role of Non-Neuronal Cells in Stress Disorders. Neuron, 2022, S0896-6273(22)00102-7. DOI: https://doi.org/10.1016/j.neuron.2022.01.033.

H. Ekhtiari, P. Ghobadi-Azbari, A. Thielscher, A. Antal, L. M. Li, A. D. Shereen, Y. Cabral-Calderin, D. Keeser, T. O. Bergmann, A. Jamil, I. R. Violante, J. Almeida, M. Meinzer, H. R. Siebner, A. J. Woods, C. J. Stagg, R. Abend, D. Antonenko, T. Auer, M. Bächinger, et al. A Checklist for Assessing the Methodological Quality of Concurrent TES-FMRI Studies (ContES Checklist): A Consensus Study and Statement. Nat Protoc, 2022, 17 (3), 596–617. DOI: https://doi.org/10.1038/s41596-021-00664-5.

H. W. Korsmo, B. Dave, S. Trasino, A. Saxena, J. Liu, J. M. Caviglia, K. Edwards, M. Dembitzer, S. Sheeraz, S. Khaldi, X. Jiang. Maternal Choline Supplementation and High-Fat Feeding Interact to Influence DNA Methylation in Offspring in a Time-Specific Manner. Frontiers in Nutrition, 2022, 9.

A. Ntranos, H. J. Park, M. Wentling, V. Tolstikov, M. Amatruda, B. Inbar, S. Kim-Schulze, C. Frazier, J. Button, M. A. Kiebish, F. Lublin, K. Edwards, P. Casaccia. Bacterial Neurotoxic Metabolites in Multiple Sclerosis Cerebrospinal Fluid and Plasma. Brain, 2021, awab320. DOI: https://doi.org/10.1093/brain/awab320. Video Abstract

T. Roostaei, H.-U. Klein, Y. Ma, D. Felsky, P. Kivisäkk, S. M. Connor, A. Kroshilina, C. Yung, B. J. Kaskow, X. Shao, B. Rhead, J. M. Ordovás, D. M. Absher, D. K. Arnett, J. Liu, N. Patsopoulos, L. F. Barcellos, H. L. Weiner, P. L. De Jager. Proximal and Distal Effects of Genetic Susceptibility to Multiple Sclerosis on the T Cell Epigenome. Nat Commun, 2021, 12 (1), 7078. DOI: https://doi.org/10.1038/s41467-021-27427-w.

Kim JW, Yin X, Martin I, Xiong Y, Eacker SM, Ingolia NT, et al. Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains. Eneuro. 2021;8:ENEURO.0310-21.2021. doi:10.1523/eneuro.0310-21.2021 PubMed PMID: 34759048; PubMed Central PMCID: PMC8638676.

D. Marechal, D. K. Dansu, K. Castro, J. Patzig, L. Magri, B. Inbar, M. Gacias, S. Moyon, P. Casaccia. N-Myc Downstream Regulated Family Member 1 (NDRG1) Is Enriched in Myelinating Oligodendrocytes and Impacts Myelin Degradation in Response to Demyelination. Glia. 2021 Oct 23. DOI: https://doi.org/10.1002/glia.24108.

R.H. Huang, N. Nayeem, Y. He, J. Morales, D. Graham, R. Klajn, M. Contel, S. O’Brien, and R.V. Ulijn. Self‐Complementary Zwitterionic Peptides Direct Nanoparticle Assembly and Enable Enzymatic Selection of Endocytic Pathways, Adv. Mater., 2021, 2104962, DOI: https://doi.org/10.1002/adma.202104962.

F. Li, T. Y. Lo, L. Miles, Q. Wang, H. N. Noristani, D. Li, J. Niu, S. Trombley, J. I. Goldshteyn, C. Wang, S. Wang, J. Qiu, K. Pogoda, K. Mandal, M. Brewster, P. Rompolas, Y. He, P. A. Janmey, G. M. Thomas, S. Li, Y. Song. The Atr-Chek1 Pathway Inhibits Axon Regeneration in Response to Piezo-Dependent Mechanosensation. Nat Commun, 2021, 12 (1), 3845. DOI: https://doi.org/10.1038/s41467-021-24131-7.

S. Moyon, R. Frawley, D. Marechal, D. Huang, K. L. H. Marshall-Phelps, L. Kegel, S. M. K. Bøstrand, B. Sadowski, Y.-H. Jiang, D. A. Lyons, W. Möbius, P. Casaccia. TET1-Mediated DNA Hydroxymethylation Regulates Adult Remyelination in Mice. Nat Commun, 2021, 12 (1), 3359. DOI: https://doi.org/10.1038/s41467-021-23735-3.

D. Chang, Q. Brown, G. Tsui, Y. He, J. Liu, L. Shi, A. Rodríguez-Contreras. Distinct Cellular Profiles of Hif1a and Vegf MRNA Localization in Microglia, Astrocytes and Neurons during a Period of Vascular Maturation in the Auditory Brainstem of Neonate Rats. Brain Sciences, 2021, 11 (7), 944. DOI: https://doi.org/10.3390/brainsci11070944.

Daniel Eskenazi, Lauren Malave, Susana Mingote, Leora Yetnikoff, Samira Ztaou, Vlad Velicu, Stephen Rayport, Nao Chuhma, Dopamine neurons that cotransmit glutamate, from synapses to circuits to behavior, Frontiers in Neural Circuits vol. 15, 2021. doi: 10.3389/fncir.2021.665386

J. Yin, E. Spillman, E. S. Cheng, J. Short, Y. Chen, J. Lei, M. Gibbs, J. S. Rosenthal, C. Sheng, Y. X. Chen, K. Veerasammy, T. Choetso, R. Abzalimov, B. Wang, C. Han, Y. He, Q. Yuan. Brain-Specific Lipoprotein Receptors Interact with Astrocyte Derived Apolipoprotein and Mediate Neuron-Glia Lipid Shuttling. Nature Communications, 2021, 12 (1), 2408. DOI: https://doi.org/10.1038/s41467-021-22751-7.

A. Lampel, S.A. McPhee, S. Kassem, D. Sementa, T. Massarano, J. M. Aramini, Y. He, and R. V. Ulijn, Melanin-Inspired Chromophoric Microparticles Composed of Polymeric Peptide Pigments, Angew Chem Int Ed Engl, 2021, 60, 7564-7569.

E. S. Duncan, A. D. Shereen, T. Gentimis, S. L. Small. Identifiable Patterns of Trait, State, and Experience in Chronic Stroke Recovery. Neurorehabil Neural Repair, 2021, 35 (2), 158–168. DOI: https://doi.org/10.1177/1545968320981953.

J. Liu, E. Likhtik, A. D. Shereen, T. A. Dennis-Tiwary, P. Casaccia. White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination. Front Cell Neurosci, 2020, 14, 587053. DOI: https://doi.org/10.3389/fncel.2020.587053.

P. Ghobadi-Azbari, A. Jamil, F. Yavari, Z. Esmaeilpour, N. Malmir, R. Mahdavifar-Khayati, G. Soleimani, Y.-H. Cha, A. D. Shereen, M. A. Nitsche, M. Bikson, H. Ekhtiari. FMRI and Transcranial Electrical Stimulation (TES): A Systematic Review of Parameter Space and Outcomes. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 110149. DOI: https://doi.org/10.1016/j.pnpbp.2020.110149.

D. K. Dansu, S. Sauma, P. Casaccia. Oligodendrocyte Progenitors as Environmental Biosensors. Semin Cell Dev Biol, 2020. DOI: https://doi.org/10.1016/j.semcdb.2020.09.012.

Kim JW, Yin X, Jhaldiyal A, Khan MR, Martin I, Xie Z, et al. Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis. Cell Stem Cell. 2020;27:633-645.e7. doi:10.1016/j.stem.2020.08.002 PubMed PMID: 32846140; PubMed Central PMCID: PMC7542555.

A. Badimon, H. J. Strasburger, P. Ayata, X. Chen, A. Nair, A. Ikegami, P. Hwang, A. T. Chan, S. M. Graves, J. O. Uweru, C. Ledderose, M. G. Kutlu, M. A. Wheeler, A. Kahan, M. Ishikawa, Y.-C. Wang, Y.-H. E. Loh, J. X. Jiang, D. J. Surmeier, S. C. Robson, et al. Negative Feedback Control of Neuronal Activity by Microglia. Nature, 2020, 586 (7829), 417–423. DOI: https://doi.org/10.1038/s41586-020-2777-8.

M. Amatruda, M. Petracca, M. Wentling, B. Inbar, K. Castro, E. Y. Chen, M. A. Kiebish, K. Edwards, M. Inglese, P. Casaccia. Retrospective Unbiased Plasma Lipidomic of Progressive Multiple Sclerosis Patients-Identifies Lipids Discriminating Those with Faster Clinical Deterioration. Scientific Reports, 2020, 10 (1), 15644. DOI: https://doi.org/10.1038/s41598-020-72654-8.

Jeff A Beeler, Devry Mourra, Roseanna M Zanca, Abigail Kalmbach, Celia Gellman, Benjamin Y Klein, Rebecca Ravenelle, Peter Serrano, Holly Moore, Stephen Rayport, Susana Mingote, Nesha S Burghardt, Vulnerable and resilient phenotypes in a mouse model of anorexia nervosa. Biological Psychiatry 2020

S. L. Lim, C. J. Rodriguez-Ortiz, H.-W. Hsu, J. Wu, J. Zumkehr, J. Kilian, J. Vidal, P. Ayata, M. Kitazawa. Chronic Copper Exposure Directs Microglia towards Degenerative Expression Signatures in Wild-Type and J20 Mouse Model of Alzheimer’s Disease. Journal of Trace Elements in Medicine and Biology, 2020, 62, 126578. DOI: https://doi.org/10.1016/j.jtemb.2020.126578.

P. Casaccia, E. W. G. M. Boddeke. Foreword. Glia, 2020, 68 (8), 1551–1553. DOI: https://doi.org/10.1002/glia.23841.

G. M. Dmochowski, A. D. Shereen, D. Berisha, J. P. Dmochowski. Near-Infrared Light Increases Functional Connectivity with a Non-Thermal Mechanism. Cerebral Cortex Communications, 2020, 1 (1), tgaa004. DOI: https://doi.org/10.1093/texcom/tgaa004.

Samudyata, G. Castelo‐Branco, J. Liu. Epigenetic Regulation of Oligodendrocyte Differentiation: From Development to Demyelinating Disorders. Glia, 2020, glia.23820. DOI: https://doi.org/10.1002/glia.23820.

S. Sauma, P. Casaccia. Gut-Brain Communication in Demyelinating Disorders. Current Opinion in Neurobiology, 2020, 62, 92–101. DOI: https://doi.org/10.1016/j.conb.2020.01.005.

C. Yattah, M. Hernandez, D. Huang, H. Park, W. Liao, P. Casaccia. Dynamic Lamin B1-Gene Association During Oligodendrocyte Progenitor Differentiation. Neurochem Res, 2020. DOI: https://doi.org/10.1007/s11064-019-02941-y.

P. Ayata, A. Schaefer. Innate Sensing of Mechanical Properties of Brain Tissue by Microglia. Current Opinion in Immunology, 2020, 62, 123–130. DOI: https://doi.org/10.1016/j.coi.2020.01.003.

P. Shrestha, P. Ayata*, P. Herrero-Vidal, F. Longo, A. Gastone, J. E. LeDoux, N. Heintz, E. Klann. Cell-Type-Specific Drug-Inducible Protein Synthesis Inhibition Demonstrates That Memory Consolidation Requires Rapid Neuronal Translation. Nat Neurosci, 2020, 23 (2), 281–292. DOI: https://doi.org/10.1038/s41593-019-0568-z. (* co-first author)

Z. Esmaeilpour, A. D. Shereen, P. Ghobadi‐Azbari, A. Datta, A. J. Woods, M. Ironside, J. O’Shea, U. Kirk, M. Bikson, H. Ekhtiari. Methodology for TDCS Integration with FMRI. Hum Brain Mapp, 2020, 41 (7), 1950–1967. DOI: https://doi.org/10.1002/hbm.24908.

B. J. Piggott, C. J. Peters, Y. He, X. Huang, S. Younger, L. Y. Jan, Y. N. Jan. Paralytic, the Drosophila Voltage-Gated Sodium Channel, Regulates Proliferation of Neural Progenitors. Genes Dev., 2019, 33 (23–24), 1739–1750. DOI: https://doi.org/10.1101/gad.330597.119.

S. Sauma, P. Casaccia. Does the Gut Microbiota Contribute to the Oligodendrocyte Progenitor Niche? Neuroscience Letters, 2019, 134574. DOI: https://doi.org/10.1016/j.neulet.2019.134574.

Mingote S*, Amsellem A, Kempf A, Rayport S, Chuhma N. Dopamine-Glutamate Neuron Projections to the Nucleus Accumbens Medial Shell and Behavioral Switching. In special issue: The physiology and pathophysiology of basal ganglia. Neurochemistry International, 2019; 129: 104482. Review. doi: 10.1016/j.neuint.2019.104482

Lauren Kosten, Golam MI Chowdhury, Susana Mingote, Steven Staelens, Douglas L Rothman, Kevin L Behar, Stephen Rayport, Glutaminase activity in GLS1 Het mouse brain compared to putative pharmacological inhibition by ebselen using ex vivo MRS. Neurochemistry international vol. 129, p. 104508

M. Wentling, C. Lopez-Gomez, H.J. Park, M. Amatruda, A. Ntranos, J. Aramini, M. Petracca, T. Rusielewicz, E. Chen, V. Tolstikov, M. Kiebish, V. Fossati, M. Inglese, C.M. Quinzii, I. Katz Sand, P. Casaccia. A metabolic perspective on CSF-mediated neurodegeneration in multiple sclerosis. Brain, 2019. DOI: 10.1093/brain/awz201 (press release)

V. Bonnefil, K. Dietz, M. Amatruda, M. Wentling, A.V. Aubry, J.L. Dupree, G. Temple, H.J. Park, N.S. Burghardt, P. Casaccia, J. Liu. Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice. ELife, 2019, 8. DOI: 10.7554/eLife.40855.001. Podcast: https://elifesciences.org/podcast/episode60#933.

L.L. Boshans, D.C. Factor, V. Singh, J. Liu, C. Zhao, I. Mandoiu, Q.R. Lu, P. Casaccia, P.J. Tesar, A. Nishiyama. The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming. Frontiers in Neuroscience, 2019, 13. DOI: 10.3389/fnins.2019.00829

V. Kana, F. A. Desland, M. Casanova-Acebes, P. Ayata, A. Badimon, E. Nabel, K. Yamamuro, M. Sneeboer, I.-L. Tan, M. E. Flanigan, S. A. Rose, C. Chang, A. Leader, H. Le Bourhis, E. S. Sweet, N. Tung, A. Wroblewska, Y. Lavin, P. See, A. Baccarini, et al. CSF-1 Controls Cerebellar Microglia and Is Required for Motor Function and Social Interaction. Journal of Experimental Medicine, 2019, 216 (10), 2265–2281. DOI: https://doi.org/10.1084/jem.20182037.

P. Shrestha, P. Ayata*, P. Herrero-Vidal, A. Gastone, JE LeDoux, N. Heintz, E. Klann. Chemogenetic evidence that rapid neuronal de novo protein synthesis is required for consolidation of long-term memory. bioRxiv. 2019 704965 (* co-first author)

G. Gunner, L. Cheadle, K. M. Johnson, P. Ayata, A. Badimon, E. Mondo, M. A. Nagy, L. Liu, S. M. Bemiller, K.-W. Kim, S. A. Lira, B. T. Lamb, A. R. Tapper, R. M. Ransohoff, M. E. Greenberg, A. Schaefer, D. P. Schafer. Sensory Lesioning Induces Microglial Synapse Elimination via ADAM10 and Fractalkine Signaling. Nat Neurosci, 2019, 22 (7), 1075–1088. DOI: https://doi.org/10.1038/s41593-019-0419-y.

K. Castro, A. Ntranos, M. Amatruda, M. Petracca, P. Kosa, E.Y. Chen, J. Morstein, D. Trauner, C.T. Watson, M.A. Kiebish, B. Bielekova, M. Inglese, I. Katz Sand, P. Casaccia. Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course. EBioMedicine, 2019. DOI: 10.1016/j.ebiom.2019.03.087 (press release)

A.M. Falcão, M. Meijer, A. Scaglione, P. Rinwa, E. Agirre, J. Liang, S.C. Larsen, A. Heskol, R. Frawley, M. Klingener, M. Varas-Godoy, A.A.S.F. Raposo, P. Ernfors, D.S. Castro, M.L. Nielsen, P. Casaccia, G. Castelo-Branco. PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. Cell Reports, 2019, 4. DOI: 10.1016/j.celrep.2019.03.108

Tsai, P. Casaccia. Mechano-Modulation of Nuclear Events Regulating Oligodendrocyte Progenitor Gene Expression. Glia, 2019, 67 (7), 1229–1239. DOI: https://doi.org/10.1002/glia.23595.

A. Ntranos, V. Ntranos, V. Bonnefil, J. Liu, S. Kim-Schulze, Y. He, Y. Zhu, R. Brandstadter, C.T. Watson, A.J. Sharp, I. Katz Sand, P. Casaccia. Fumarates target the metabolic-epigenetic interplay of brain-homing T cells in multiple sclerosis. Brain, 2019, 142(3), 647-661. DOI: 10.1093/brain/awy344

V. Aubry, H. Khandaker, R. Ravenelle, I. S. Grunfeld, V. Bonnefil, K. L. Chan, F. Cathomas, J. Liu, G. E. Schafe, N. S. Burghardt. A Diet Enriched with Curcumin Promotes Resilience to Chronic Social Defeat Stress. Neuropsychopharmacol, 2019, 44 (4), 733–742. DOI: https://doi.org/10.1038/s41386-018-0295-2.

E. Cekanaviciute, A. Pröbstel, A. Thomann, T.F. Runia, P. Casaccia, I.K. Sand, E. Crabtree, S. Singh, J. Morrissey, P. Barba, R. Gomez, R. Knight, S. Mazmanian, J. Graves, B.A.C. Cree, S.S. Zamvil, S.E. Baranzini. Multiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria. mSystems, 2018 Nov 6;3(6):e00083-18.. DOI: doi.org/10.1128/msystems.00083-18

A. Ntranos, P. Casaccia. The Microbiome-Gut-Behavior Axis: Crosstalk Between the Gut Microbiome and Oligodendrocytes Modulates Behavioral Responses. Neurotherapeutics. 2018 Jan, 15 ,1, 31-35. DOI: 10.1007/s13311-017-0597-9

K. Castro, P. Casaccia. Epigenetic modifications in brain and immune cells of multiple sclerosis patients. Mult Scler, 2018. DOI: 10.1177/1352458517737389.

P. Casaccia, G. Corfas. Introduction to the special issue on myelin plasticity in the central nervous system. Dev Neurobiol, 2018. DOI: 10.1002/dneu.22575.

A. Schlüter, J. Sandoval, S. Fourcade, A. Díaz-Lagares, M. Ruiz, P. Casaccia, M. Esteller, A. Pujol. Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation. Brain Pathol, 2018. DOI: 10.1111/bpa.12595.

A.T. McKenzie, M. Wang, M.E. Hauberg, J.F. Fullard, A. Kozlenkov, A. Keenan, Y.L. Hurd, S. Dracheva, P. Casaccia, P. Roussos, B. Zhang. Brain Cell Type Specific Gene Expression and Co-expression Network Architectures. Sci Rep, 2018. DOI: 10.1038/s41598-018-27293-5.

A. Scaglione, J. Patzig, J. Liang, R. Frawley, J. Bok, A. Mela, C. Yattah, J. Zhang, S.X. Teo, T. Zhou, S. Chen, E. Bernstein, P. Canoll, E. Guccione, P. Casaccia. PRMT5-mediated regulation of developmental myelination. Nat Commun, 2018. DOI: 10.1038/s41467-018-04863-9.

I. K. Sand, Y. Zhu, A. Ntranos, J.C. Clemente, E. Cekanaviciute, R. Brandstadter, E. Crabtree-Hartman, S. Singh, Y. Bencosme, J. Debelius, R. Knight, B.A.C. Cree, S.E. Baranzini, P. Casaccia. Disease-modifying therapies alter gut microbial composition in MS. Neurology – Neuroimmunology Neuroinflammation, 2018, 6, 1. DOI: 10.1212/nxi.0000000000000517

A. Pathak, E.M. Stanley, F.E. Hickman, N. Wallace, B. Brewer, D. Li, S. Gluska, E. Perlson, S. Fuhrmann, K. Akassoglou, F. Bronfman, P. Casaccia, D.T. Burnette, B.D. Carter. Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1. Developmental cell, 2018 Aug 6;46(3):376-387.e7.. DOI: doi.org/10.1016/j.devcel.2018.07.001

P. Ayata, A. Badimon, H. J. Strasburger, M. K. Duff, S. E. Montgomery, Y.-H. E. Loh, A. Ebert, A. A. Pimenova, B. R. Ramirez, A. T. Chan, J. M. Sullivan, I. Purushothaman, J. R. Scarpa, A. M. Goate, M. Busslinger, L. Shen, B. Losic, A. Schaefer. Epigenetic Regulation of Brain Region-Specific Microglia Clearance Activity. Nat Neurosci, 2018, 21 (8), 1049–1060. DOI: https://doi.org/10.1038/s41593-018-0192-3.

R.W. Motl, E.M. Mowry, D.M. Ehde, N.G. LaRocca, K.E. Smith, K. Costello, L. Shinto, A.V. Ng, A.B. Sullivan, B. Giesser, K.K. McCully, B. Fernhall, M. Bishop, M. Plow, P. Casaccia, N.D. Chiaravalloti. Wellness and multiple sclerosis: The National MS Society establishes a Wellness Research Working Group and research priorities. Multiple sclerosis (Houndmills, Basingstoke, England), 2018 Mar;24(3):262-267.. DOI: doi.org/10.1177/1352458516687404

J. Liu, K. Dietz, G.E. Hodes, S.J. Russo, P. Casaccia. Widespread transcriptional alternations in oligodendrocytes in the adult mouse brain following chronic stress. Developmental neurobiology, 2018 Feb;78(2):152-162.. DOI: doi.org/10.1002/dneu.22533

A.T. McKenzie, S. Moyon, M. Wang, I. Katsyv, W. Song, X. Zhou, E.B. Dammer, D.M. Duong, J. Aaker, Y. Zhao, N. Beckmann, P. Wang, J. Zhu, J.J. Lah, N.T. Seyfried, A.I. Levey, P. Katsel, V. Haroutunian, E.E. Schadt, B. Popko, P. Casaccia, B. Zhang. Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease. Molecular neurodegeneration, 2017 Nov 6;12(1):82.. DOI: doi.org/10.1186/s13024-017-0219-3

M. Mellén, P. Ayata, N. Heintz. 5-Hydroxymethylcytosine Accumulation in Postmitotic Neurons Results in Functional Demethylation of Expressed Genes. Proc Natl Acad Sci USA, 2017, 114 (37), E7812–E7821. DOI: https://doi.org/10.1073/pnas.1708044114.

Y. Zhu, O.G. Vidaurre, K.P. Adula, N. Kezunovic, M. Wentling, G.W. Huntley, P. Casaccia. Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017 Aug 2;37(31):7547-7559.. DOI: doi.org/10.1523/jneurosci.3000-16.2017

D. Mathur, A.L. Riffo-Campos, J. Castillo, J.D. Haines, O.G. Vidaurre, F. Zhang, F. Coret-Ferrer, P. Casaccia, B. Casanova, G. Lopez-Rodas. Bioenergetic Failure in Rat Oligodendrocyte Progenitor Cells Treated with Cerebrospinal Fluid Derived from Multiple Sclerosis Patients. Frontiers in cellular neuroscience, 2017 Jul 18;11:209.. DOI: doi.org/10.3389/fncel.2017.00209

A.M. Dickens, L.B. Tovar-Y-Romo, S. Yoo, A.L. Trout, M. Bae, M. Kanmogne, B. Megra, D.W. Williams, K.W. Witwer, M. Gacias, N. Tabatadze, R.N. Cole, P. Casaccia, J.W. Berman, D.C. Anthony, N.J. Haughey. Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions. Science signaling, 2017 Apr 4;10(473):eaai7696.. DOI: doi.org/10.1126/scisignal.aai7696

S. Moyon, D. Ma, J.L. Huynh, D.J.C. Coutts, C. Zhao, P. Casaccia, R.J.M. Franklin. Efficient Remyelination Requires DNA Methylation. eNeuro, 2017 Mar 30;4(2):ENEURO.0336-16.2017.. DOI: doi.org/10.1523/eneuro.0336-16.2017

S. Moyon, P. Casaccia. DNA methylation in oligodendroglial cells during developmental myelination and in disease. Neurogenesis (Austin, Tex.), 2017 Jan 31;4(1):e1270381.. DOI: doi.org/10.1080/23262133.2016.1270381

M. Wang, P. Roussos, A. McKenzie, X. Zhou, Y. Kajiwara, K.J. Brennand, G.C.D. Luca, J.F. Crary, P. Casaccia, J.D. Buxbaum, M. Ehrlich, S. Gandy, A. Goate, P. Katsel, E. Schadt, V. Haroutunian, B. Zhang. Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease. Genome medicine, 2016 Nov 1;8(1):104.. DOI: doi.org/10.1186/s13073-016-0355-3

J. Liu, S. Moyon, M. Hernandez, P. Casaccia. Epigenetic control of oligodendrocyte development: adding new players to old keepers. Current opinion in neurobiology, 2016 Aug;39:133-8.. DOI: doi.org/10.1016/j.conb.2016.06.002

A. Ntranos, P. Casaccia. Bromodomains: Translating the words of lysine acetylation into myelin injury and repair. Neuroscience letters, 2016 Jun 20;625:4-10. DOI: doi.org/10.1016/j.neulet.2015.10.015

B.M. Laitman, L. Asp, J.N. Mariani, J. Zhang, J. Liu, S. Sawai, C. Chapouly, S. Horng, E.G. Kramer, N. Mitiku, H. Loo, N. Burlant, X. Pedre, Y. Hara, G. Nudelman, E. Zaslavsky, Y. Lee, D.A. Braun, Q.R. Lu, G. Narla, C.S. Raine, S.L. Friedman, P. Casaccia, G.R. John. The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination. PLoS biology, 2016 May 23;14(5):e1002467.. DOI: doi.org/10.1371/journal.pbio.1002467

S. Moyon, J. Liang, P. Casaccia. Epigenetics in NG2 glia cells. Brain research, 2016 May 1;1638(Pt B):183-198.. DOI: doi.org/10.1016/j.brainres.2015.06.009

S. Moyon, J.L. Huynh, D. Dutta, F. Zhang, D. Ma, S. Yoo, R. Lawrence, M. Wegner, G.R. John, B. Emery, C. Lubetzki, R.J.M. Franklin, G. Fan, J. Zhu, J.L. Dupree, P. Casaccia. Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage. Cell reports, 2016 Apr 26;15(4):748-760. DOI: doi.org/10.1016/j.celrep.2016.03.060

P. Douvaras, T. Rusielewicz, K.H. Kim, J.D. Haines, P. Casaccia, V. Fossati. Epigenetic Modulation of Human Induced Pluripotent Stem Cell Differentiation to Oligodendrocytes. International journal of molecular sciences, 2016 Apr 22;17(4):614.. DOI: doi.org/10.3390/ijms17040614

M. Hernandez, J. Patzig, S.R. Mayoral, K.D. Costa, J.R. Chan, P. Casaccia. Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016 Jan 20;36(3):806-13. DOI: doi.org/10.1523/jneurosci.2873-15.2016

J. Liu, J.L. Dupree, M. Gacias, R. Frawley, T. Sikder, P. Naik, P. Casaccia. Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016 Jan 20;36(3):957-62. DOI: doi.org/10.1523/jneurosci.3608-15.2016

J. M. Sullivan, A. Badimon, U. Schaefer, P. Ayata, J. Gray, C. Chung, M. von Schimmelmann, F. Zhang, N. Garton, N. Smithers, H. Lewis, A. Tarakhovsky, R. K. Prinjha, A. Schaefer. Autism-like Syndrome Is Induced by Pharmacological Suppression of BET Proteins in Young Mice. Journal of Experimental Medicine, 2015, 212 (11), 1771–1781. DOI: https://doi.org/10.1084/jem.20151271.

H. Rolyan, Y.Y. Tyurina, M. Hernandez, A.A. Amoscato, L.J. Sparvero, B.C. Nmezi, Y. Lu, M.R.H. Estécio, K. Lin, J. Chen, R. He, P. Gong, L.H. Rigatti, J. Dupree, H. Bayır, V.E. Kagan, P. Casaccia, Q.S. Padiath. Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015 Aug 26;35(34):12002-17. DOI: doi.org/10.1523/jneurosci.1668-15.2015

C. Zhao, D. Ma, M. Zawadzka, S.P.J. Fancy, L. Elis-Williams, G. Bouvier, J.H. Stockley, G.M.d. Castro, B. Wang, S. Jacobs, P. Casaccia, R.J.M. Franklin. Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015 Aug 19;35(33):11482-99. DOI: doi.org/10.1523/jneurosci.3655-14.2015

X. Huang*, Y. He*, A. M. Dubuc, R. Hashizume, W. Zhang, J. Reimand, H. Yang, T. A. Wang, S. J. Stehbens, S. Younger, S. Barshow, S. Zhu, M. K. Cooper, J. Peacock, V. Ramaswamy, L. Garzia, X. Wu, M. Remke, C. M. Forester, C. C. Kim, et al. EAG2 Potassium Channel with Evolutionarily Conserved Function as a Brain Tumor Target. Nat Neurosci, 2015, 18 (9), 1236–1246. DOI: https://doi.org/10.1038/nn.4088. (* equal contribution)

M. Hernandez, P. Casaccia. Interplay between transcriptional control and chromatin regulation in the oligodendrocyte lineage. Glia, 2015 Aug;63(8):1357-75. DOI: doi.org/10.1002/glia.22818

J. Feng, N. Shao, K.E. Szulwach, V. Vialou, J. Huynh, C. Zhong, T. Le, D. Ferguson, M.E. Cahill, Y. Li, J.W. Koo, E. Ribeiro, B. Labonte, B.M. Laitman, D. Estey, V. Stockman, P. Kennedy, T. Couroussé, I. Mensah, G. Turecki, K.F. Faull, G. Ming, H. Song, G. Fan, P. Casaccia, L. Shen, P. Jin, E.J. Nestler. Role of Tet1 and 5-hydroxymethylcytosine in cocaine action. Nature neuroscience, 2015 Apr;18(4):536-44. DOI: doi.org/10.1038/nn.3976

J.D. Haines, O. Herbin, B.d.l. Hera, O.G. Vidaurre, G.A. Moy, Q. Sun, H.Y.J. Fung, S. Albrecht, K. Alexandropoulos, D. McCauley, Y.M. Chook, T. Kuhlmann, G.J. Kidd, S. Shacham, P. Casaccia. Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination. Nature neuroscience, 2015 Apr;18(4):511-20. DOI: doi.org/10.1038/nn.3953

J. Liu, L. Magri, F. Zhang, N.O. Marsh, S. Albrecht, J.L. Huynh, J. Kaur, T. Kuhlmann, W. Zhang, P.A. Slesinger, P. Casaccia. Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015 Jan 7;35(1):352-65. DOI: doi.org/10.1523/jneurosci.2606-14.2015

L. Magri, M. Gacias, M. Wu, V.A. Swiss, W.G. Janssen, P. Casaccia. c-Myc-dependent transcriptional regulation of cell cycle and nucleosomal histones during oligodendrocyte differentiation. Neuroscience, 2014 Sep 12;276:72-86. DOI: doi.org/10.1016/j.neuroscience.2014.01.051

O.G. Vidaurre, J.D. Haines, I.K. Sand, K.P. Adula, J.L. Huynh, C.A. McGraw, F. Zhang, M. Varghese, E. Sotirchos, P. Bhargava, V.V.R. Bandaru, G. Pasinetti, W. Zhang, M. Inglese, P.A. Calabresi, G. Wu, A.E. Miller, N.J. Haughey, F.D. Lublin, P. Casaccia. Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics. Brain : a journal of neurology, 2014 Aug;137(Pt 8):2271-86.. DOI: doi.org/10.1093/brain/awu139

M. Narayanan, J.L. Huynh, K. Wang, X. Yang, S. Yoo, J. McElwee, B. Zhang, C. Zhang, J.R. Lamb, T. Xie, C. Suver, C. Molony, S. Melquist, A.D. Johnson, G. Fan, D.J. Stone, E.E. Schadt, P. Casaccia, V. Emilsson, J. Zhu. Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases. Molecular systems biology, 2014 Jul 30;10(7):743.. DOI: doi.org/10.15252/msb.20145304

M. Gacias, G. Gerona-Navarro, A.N. Plotnikov, G. Zhang, L. Zeng, J. Kaur, G. Moy, E. Rusinova, Y. Rodriguez, B. Matikainen, A. Vincek, J. Joshua, P. Casaccia, M. Zhou. Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression. Chemistry & biology, 2014 Jul 17;21(7):841-854.. DOI: doi.org/10.1016/j.chembiol.2014.05.009

D.J. Dutta, A. Zameer, J.N. Mariani, J. Zhang, L. Asp, J. Huynh, S. Mahase, B.M. Laitman, A.T. Argaw, N. Mitiku, M. Urbanski, C.V. Melendez-Vasquez, P. Casaccia, F. Hayot, E.P. Bottinger, C.W. Brown, G.R. John. Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination. Development (Cambridge, England), 2014 Jun;141(12):2414-28.. DOI: doi.org/10.1242/dev.106492

Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, et al. Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease. Cell. 2014;157:472–85. doi:10.1016/j.cell.2014.01.064

M. Gacias, P. Casaccia. EPIGENETIC MECHANISMS IN MULTIPLE SCLEROSIS. Revista espanola de esclerosis multiple, 2014 Mar;6(29):25-35

L. Magri, V.A. Swiss, B. Jablonska, L. Lei, X. Pedre, M. Walsh, W. Zhang, V. Gallo, P. Canoll, P. Casaccia. E2F1 coregulates cell cycle genes and chromatin components during the transition of oligodendrocyte progenitors from proliferation to differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014 Jan 22;34(4):1481-93.. DOI: doi.org/10.1523/jneurosci.2840-13.2014

J.L. Huynh, P. Garg, T.H. Thin, S. Yoo, R. Dutta, B.D. Trapp, V. Haroutunian, J. Zhu, M.J. Donovan, A.J. Sharp, P. Casaccia. Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains. Nature neuroscience, 2014 Jan;17(1):121-30.. DOI: doi.org/10.1038/nn.3588

M. Gacias, P. Casaccia. Promoting return of function in multiple sclerosis: An integrated approach. Multiple sclerosis and related disorders, 2013 Oct 1;2(4):10.1016/j.msard.2013.04.002.. DOI: doi.org/10.1016/j.msard.2013.04.002

R. Bharadwaj, Y. Jiang, W. Mao, M. Jakovcevski, A. Dincer, W. Krueger, K. Garbett, C. Whittle, J.S. Tushir, J. Liu, A. Sequeira, M.P. Vawter, P.D. Gardner, P. Casaccia, T. Rasmussen, W.E.B. Jr, K. Mirnics, K. Futai, S. Akbarian. Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013 Jul 17;33(29):11839-51.. DOI: doi.org/10.1523/jneurosci.1252-13.2013

J.L. Huynh, P. Casaccia. Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment. The Lancet. Neurology, 2013 Feb;12(2):195-206.. DOI: doi.org/10.1016/s1474-4422(12)70309-5

M. Mellén, P. Ayata*, S. Dewell, S. Kriaucionis, N. Heintz. MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System. Cell, 2012, 151 (7), 1417–1430. DOI: https://doi.org/10.1016/j.cell.2012.11.022. (* co-first author)

Z. Yan, W. Zhang, Y. He, D. Gorczyca, Y. Xiang, L. E. Cheng, S. Meltzer, L. Y. Jan, Y. N. Jan. Drosophila NOMPC Is a Mechanotransduction Channel Subunit for Gentle-Touch Sensation. Nature, 2013, 493 (7431), 221-225. DOI: https://doi.org/10.1038/nature11685.

J. Liu, K. Dietz, J.M. DeLoyht, X. Pedre, D. Kelkar, J. Kaur, V. Vialou, M.K. Lobo, D.M. Dietz, E.J. Nestler, J. Dupree, P. Casaccia. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nature neuroscience, 2012 Dec;15(12):1621-3.. DOI: doi.org/10.1038/nn.3263

X. Huang, A. M. Dubuc, R. Hashizume, J. Berg, Y. He, J. Wang, C. Chiang, M. K. Cooper, P. A. Northcott, M. D. Taylor, M. J. Barnes, T. Tihan, J. Chen, C. S. Hackett, W. A. Weiss, C. D. James, D. H. Rowitch, M. A. Shuman, Y. N. Jan, L. Y. Jan. Voltage-Gated Potassium Channel EAG2 Controls Mitotic Entry and Tumor Growth in Medulloblastoma via Regulating Cell Volume Dynamics. Genes & Development, 2012, 26 (16), 1780–1796. DOI: https://doi.org/10.1101/gad.193789.112.

O.G. Vidaurre, J. Liu, J. Haines, J. Sandoval, R. Nowakowski, P. Casaccia. An integrated approach to design novel therapeutic interventions for demyelinating disorders. The European journal of neuroscience, 2012 Jun;35(12):1879-86.. DOI: doi.org/10.1111/j.1460-9568.2012.08118.x

M. Wu, M. Hernandez, S. Shen, J.K. Sabo, D. Kelkar, J. Wang, R. O'Leary, G.R. Phillips, H.S. Cate, P. Casaccia. Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012 May 9;32(19):6651-64.. DOI: doi.org/10.1523/jneurosci.4876-11.2012

J.A. DiNieri, X. Wang, H. Szutorisz, S.M. Spano, J. Kaur, P. Casaccia, D. Dow-Edwards, Y.L. Hurd. Maternal cannabis use alters ventral striatal dopamine D2 gene regulation in the offspring. Biological psychiatry, 2011 Oct 15;70(8):763-769. DOI: doi.org/10.1016/j.biopsych.2011.06.027

S. Gil-Perotin, J.D. Haines, J. Kaur, M. Marin-Husstege, M.J. Spinetta, K. Kim, M. Duran-Moreno, T. Schallert, F. Zindy, M.F. Roussel, J.M. Garcia-Verdugo, P. Casaccia. Roles of p53 and p27(Kip1) in the regulation of neurogenesis in the murine adult subventricular zone. The European journal of neuroscience, 2011 Oct;34(7):1040-52.. DOI: doi.org/10.1111/j.1460-9568.2011.07836.x

P. Casaccia. Anti-TANKyrase weapons promote myelination. Nature neuroscience, 2011 Jul 26;14(8):945-7.. DOI: doi.org/10.1038/nn.2885

V.A. Swiss, T. Nguyen, J. Dugas, A. Ibrahim, B. Barres, I.P. Androulakis, P. Casaccia. Identification of a gene regulatory network necessary for the initiation of oligodendrocyte differentiation. PloS one, 2011 Apr 7;6(4):e18088.. DOI: doi.org/10.1371/journal.pone.0018088

M. Inglese, N. Oesingmann, P. Casaccia, L. Fleysher. Progressive multiple sclerosis and gray matter pathology: an MRI perspective. The Mount Sinai journal of medicine, New York, Mar-Apr 2011;78(2):258-67. DOI: doi.org/10.1002/msj.20247

J.D. Haines, M. Inglese, P. Casaccia. Axonal damage in multiple sclerosis. The Mount Sinai journal of medicine, New York, Mar-Apr 2011;78(2):231-43. DOI: doi.org/10.1002/msj.20246

X. Pedre, F. Mastronardi, W. Bruck, G. López-Rodas, T. Kuhlmann, P. Casaccia. Changed histone acetylation patterns in normal-appearing white matter and early multiple sclerosis lesions. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011 Mar 2;31(9):3435-45.. DOI: doi.org/10.1523/jneurosci.4507-10.2011

N.S. Mattan, C.A. Ghiani, M. Lloyd, R. Matalon, D. Bok, P. Casaccia, J.d. Vellis. Aspartoacylase deficiency affects early postnatal development of oligodendrocytes and myelination. Neurobiology of disease, 2010 Nov;40(2):432-43.. DOI: doi.org/10.1016/j.nbd.2010.07.003

J. Liu, J. Sandoval, S.T. Doh, L. Cai, G. López-Rodas, P. Casaccia. Epigenetic modifiers are necessary but not sufficient for reprogramming non-myelinating cells into myelin gene-expressing cells. PloS one, 2010 Sep 27;5(9):e13023.. DOI: doi.org/10.1371/journal.pone.0013023

J.Y. Kim, P. Casaccia. HDAC1 in axonal degeneration: A matter of subcellular localization. Cell cycle (Georgetown, Tex.), 2010 Sep 15;9(18):3680-4.. DOI: doi.org/10.4161/cc.9.18.12716

K.C. Dietz, P. Casaccia. HDAC inhibitors and neurodegeneration: at the edge between protection and damage. Pharmacological research, 2010 Jul;62(1):11-7.. DOI: doi.org/10.1016/j.phrs.2010.01.011

J.L. Huynh, P. Casaccia. Defining the chromatin landscape in demyelinating disorders. Neurobiology of disease, 2010 Jul;39(1):47-52.. DOI: doi.org/10.1016/j.nbd.2009.10.014

D. Kerns, G.S. Vong, K. Barley, S. Dracheva, P. Katsel, P. Casaccia, V. Haroutunian, W. Byne. Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophrenia. Schizophrenia research, 2010 Jul;120(1-3):150-8.. DOI: doi.org/10.1016/j.schres.2010.04.012

I. Germano, V. Swiss, P. Casaccia. Primary brain tumors, neural stem cell, and brain tumor cancer cells: where is the link?. Neuropharmacology, 2010 May;58(6):903-10.. DOI: doi.org/10.1016/j.neuropharm.2009.12.019

J. Liu, P. Casaccia. Epigenetic regulation of oligodendrocyte identity. Trends in neurosciences, 2010 Apr;33(4):193-201.. DOI: doi.org/10.1016/j.tins.2010.01.007

V.A. Swiss, P. Casaccia. Cell-context specific role of the E2F/Rb pathway in development and disease. Glia, 2010 Mar;58(4):377-90.. DOI: doi.org/10.1002/glia.20933

Y. Yu, P. Casaccia, Q.R. Lu. Shaping the oligodendrocyte identity by epigenetic control. Epigenetics, 2010 Feb 16;5(2):124-8.. DOI: doi.org/10.4161/epi.5.2.11160

S. Copray, J.L. Huynh, F. Sher, P. Casaccia-Bonnefil, E. Boddeke. Epigenetic mechanisms facilitating oligodendrocyte development, maturation, and aging. Glia, 2009 Nov 15;57(15):1579-87.. DOI: doi.org/10.1002/glia.20881

J.Y. Kim, P. Casaccia-Bonnefil. Interplay of hormones and p53 in modulating gender dimorphism of subventricular zone cell number. Journal of neuroscience research, 2009 Nov 15;87(15):3297-305.. DOI: doi.org/10.1002/jnr.21940

P. Casaccia-Bonnefil, G. Pandozy, F. Mastronardi. Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis. Progress in neurobiology, 2008 Dec 11;86(4):368-78.. DOI: doi.org/10.1016/j.pneurobio.2008.09.012

S. Shen, J. Sandoval, V.A. Swiss, J. Li, J. Dupree, R.J.M. Franklin, P. Casaccia-Bonnefil. Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency. Nature neuroscience, 2008 Sep;11(9):1024-34.. DOI: doi.org/10.1038/nn.2172

J. Li, C.A. Ghiani, J.Y. Kim, A. Liu, J. Sandoval, J. DeVellis, P. Casaccia-Bonnefil. Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008 Jun 11;28(24):6118-27.. DOI: doi.org/10.1523/jneurosci.0184-08.2008

S. Shen, P. Casaccia-Bonnefil. Post-translational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease. Journal of molecular neuroscience : MN, 2008 May;35(1):13-22.. DOI: doi.org/10.1007/s12031-007-9014-x

Y. He, J. Sandoval, P. Casaccia-Bonnefil. Events at the Transition between Cell Cycle Exit and Oligodendrocyte Progenitor Differentiation: The Role of HDAC and YY1. Neuron Glia Biol., 2007, 3 (3), 221–231. DOI: https://doi.org/10.1017/S1740925X08000057.

S. Shen, A. Liu, J. Li, C. Wolubah, P. Casaccia-Bonnefil. Epigenetic memory loss in aging oligodendrocytes in the corpus callosum. Neurobiology of aging, 2008 Mar;29(3):452-63.. DOI: doi.org/10.1016/j.neurobiolaging.2006.10.026

H.B. Werner, K. Kuhlmann, S. Shen, M. Uecker, A. Schardt, K. Dimova, F. Orfaniotou, A. Dhaunchak, B.G. Brinkmann, W. Möbius, L. Guarente, P. Casaccia-Bonnefil, O. Jahn, K. Nave. Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007 Jul 18;27(29):7717-30.. DOI: doi.org/10.1523/jneurosci.1254-07.2007

A. Liu, Y.R. Han, J. Li, D. Sun, M. Ouyang, M.R. Plummer, P. Casaccia-Bonnefil. The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007 Jul 4;27(27):7339-43. DOI: doi.org/10.1523/jneurosci.1226-07.2007

F.G. Mastronardi, D.D. Wood, J. Mei, R. Raijmakers, V. Tseveleki, H. Dosch, L. Probert, P. Casaccia-Bonnefil, M.A. Moscarello. Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006 Nov 1;26(44):11387-96.. DOI: doi.org/10.1523/jneurosci.3349-06.2006

A. Liu, J. Li, M. Marin-Husstege, R. Kageyama, Y. Fan, C. Gelinas, P. Casaccia-Bonnefil. A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players. The EMBO journal, 2006 Oct 18;25(20):4833-42.. DOI: doi.org/10.1038/sj.emboj.7601352

S. Gil-Perotin, M. Marin-Husstege, J. Li, M. Soriano-Navarro, F. Zindy, M.F. Roussel, J. Garcia-Verdugo, P. Casaccia-Bonnefil. Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006 Jan 25;26(4):1107-16.. DOI: doi.org/10.1523/jneurosci.3970-05.2006

V.T. Cunliffe, P. Casaccia-Bonnefil. Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS. Mechanisms of development, 2006 Jan;123(1):24-30.. DOI: doi.org/10.1016/j.mod.2005.10.005

M. Neema, I. Navarro-Quiroga, M. Chechlacz, K. Gilliams-Francis, J. Liu, K. Lamonica, S.L. Lin, J.R. Naegele. DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures. Hippocampus, 2005;15(8):1057-71. DOI: doi.org/10.1002/hipo.20123

S. Gokhan, M. Marin-Husstege, S.Y. Yung, D. Fontanez, P. Casaccia-Bonnefil, M.F. Mehler. Combinatorial profiles of oligodendrocyte-selective classes of transcriptional regulators differentially modulate myelin basic protein gene expression. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005 Sep 7;25(36):8311-21.. DOI: doi.org/10.1523/jneurosci.1850-05.2005

S. Shen, J. Li, P. Casaccia-Bonnefil. Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain. The Journal of cell biology, 2005 May 23;169(4):577-89.. DOI: doi.org/10.1083/jcb.200412101

R. Bansal, M. Marin-Husstege, M. Bryant, P. Casaccia-Bonnefil. S-phase entry of oligodendrocyte lineage cells is associated with increased levels of p21Cip1. Journal of neuroscience research, 2005 May 1;80(3):360-8.. DOI: doi.org/10.1002/jnr.20454

A. Liu, C. Stadelmann, M. Moscarello, W. Bruck, A. Sobel, F.G. Mastronardi, P. Casaccia-Bonnefil. Expression of stathmin, a developmentally controlled cytoskeleton-regulating molecule, in demyelinating disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005 Jan 19;25(3):737-47.. DOI: doi.org/10.1523/jneurosci.4174-04.2005

D.P. Crockett, M. Burshteyn, C. Garcia, M. Muggironi, P. Casaccia-Bonnefil. Number of oligodendrocyte progenitors recruited to the lesioned spinal cord is modulated by the levels of the cell cycle regulatory protein p27Kip-1. Glia, 2005 Jan 15;49(2):301-8.. DOI: doi.org/10.1002/glia.20111

D.H. Kim, X. Zhao, C.H. Tu, P. Casaccia-Bonnefil, M.V. Chao. Prevention of apoptotic but not necrotic cell death following neuronal injury by neurotrophins signaling through the tyrosine kinase receptor. Journal of neurosurgery, 2004 Jan;100(1):79-87.. DOI: doi.org/10.3171/jns.2004.100.1.0079

A. Liu, M. Muggironi, M. Marin-Husstege, P. Casaccia-Bonnefil. Oligodendrocyte process outgrowth in vitro is modulated by epigenetic regulation of cytoskeletal severing proteins. Glia, 2003 Dec;44(3):264-74.. DOI: doi.org/10.1002/glia.10290

M. Marin-Husstege, M. Muggironi, D. Raban, R.P. Skoff, P. Casaccia-Bonnefil. Oligodendrocyte progenitor proliferation and maturation is differentially regulated by male and female sex steroid hormones. Developmental neuroscience, Mar-Aug 2004;26(2-4):245-54. DOI: doi.org/10.1159/000082141

A. Petrone, F. Battaglia, C. Wang, A. Dusa, J. Su, D. Zagzag, R. Bianchi, P. Casaccia-Bonnefil, O. Arancio, J. Sap. Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation. The EMBO journal, 2003 Aug 15;22(16):4121-31.. DOI: doi.org/10.1093/emboj/cdg399

P. Casaccia-Bonnefil, A. Liu. Relationship between cell cycle molecules and onset of oligodendrocyte differentiation. Journal of neuroscience research, 2003 Apr 1;72(1):1-11.. DOI: doi.org/10.1002/jnr.10565

M. Marin-Husstege, M. Muggironi, A. Liu, P. Casaccia-Bonnefil. Histone deacetylase activity is necessary for oligodendrocyte lineage progression. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002 Dec 1;22(23):10333-45.. DOI: doi.org/10.1523/jneurosci.22-23-10333.2002

D.J. Osterhout, M. Marin-Husstege, P. Abano, P. Casaccia-Bonnefil. Molecular mechanisms of enhanced susceptibility to apoptosis in differentiating oligodendrocytes. Journal of neuroscience research, 2002 Jul 1;69(1):24-9.. DOI: doi.org/10.1002/jnr.10230

F. Doetsch, J.M. Verdugo, I. Caille, A. Alvarez-Buylla, M.V. Chao, P. Casaccia-Bonnefil. Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002 Mar 15;22(6):2255-64.. DOI: doi.org/10.1523/jneurosci.22-06-02255.2002

R. Miskimins, R. Srinivasan, M. Marin-Husstege, W.K. Miskimins, P. Casaccia-Bonnefil. p27(Kip1) enhances myelin basic protein gene promoter activity. Journal of neuroscience research, 2002 Jan 1;67(1):100-5. DOI: doi.org/10.1002/jnr.10080

M. Todisco, P. Casaccia, N. Rossi. Cyclophosphamide plus somatostatin, bromocriptin, retinoids, melatonin and ACTH in the treatment of low-grade non-Hodgkin’s lymphomas at advanced stage: results of a phase II trial. Cancer biotherapy & radiopharmaceuticals, 2001 Apr;16(2):171-7.. DOI: doi.org/10.1089/108497801300189263

J. Zezula, P. Casaccia-Bonnefil, S.A. Ezhevsky, D.J. Osterhout, J.M. Levine, S.F. Dowdy, M.V. Chao, A. Koff. p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal. EMBO reports, 2001 Jan;2(1):27-34.. DOI: doi.org/10.1093/embo-reports/kve008

Z. Xiang, S. Hrabetova, S.I. Moskowitz, P. Casaccia-Bonnefil, S.R. Young, V.C. Nimmrich, H. Tiedge, S. Einheber, S. Karnup, R. Bianchi, P.J. Bergold. Long-term maintenance of mature hippocampal slices in vitro. Journal of neuroscience methods, 2000 Jun 1;98(2):145-54.. DOI: doi.org/10.1016/s0165-0270(00)00197-7

J.J. Gentry, P. Casaccia-Bonnefil, B.D. Carter. Nerve growth factor activation of nuclear factor kappaB through its p75 receptor is an anti-apoptotic signal in RN22 schwannoma cells. The Journal of biological chemistry, 2000 Mar 17;275(11):7558-65.. DOI: doi.org/10.1074/jbc.275.11.7558

P. Casaccia-Bonnefil. Cell death in the oligodendrocyte lineage: a molecular perspective of life/death decisions in development and disease. Glia, 2000 Jan 15;29(2):124-35.. DOI: doi.org/10.1002/(sici)1098-1136(20000115)29:2<124::aid-glia5>3.0.co;2-o

P. Casaccia-Bonnefil, C. Gu, M.V. Chao. Neurotrophins in cell survival/death decisions. Advances in experimental medicine and biology, 1999;468:275-82.. DOI: doi.org/10.1007/978-1-4615-4685-6_22

P. Dowling, X. Ming, S. Raval, W. Husar, P. Casaccia-Bonnefil, M. Chao, S. Cook, B. Blumberg. Up-regulated p75NTR neurotrophin receptor on glial cells in MS plaques. Neurology, 1999 Nov 10;53(8):1676-82. DOI: doi.org/10.1212/wnl.53.8.1676

P. Casaccia-Bonnefil, R.J. Hardy, K.K. Teng, J.M. Levine, A. Koff, M.V. Chao. Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation. Development (Cambridge, England), 1999 Sep;126(18):4027-37.

P. Casaccia-Bonnefil, C. Gu, G. Khursigara, M.V. Chao. p75 neurotrophin receptor as a modulator of survival and death decisions. Microscopy research and technique, 1999 May 15-Jun 1;45(4-5):217-24. DOI: doi.org/10.1002/(sici)1097-0029(19990515/01)45:4/5<217::aid-jemt5>3.0.co;2-5

C. Gu, P. Casaccia-Bonnefil, A. Srinivasan, M.V. Chao. Oligodendrocyte apoptosis mediated by caspase activation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999 Apr 15;19(8):3043-9.. DOI: doi.org/10.1523/jneurosci.19-08-03043.1999

E.R. Bongarzone, L. Foster, S. Byravan, P. Casaccia-Bonnefil, V. Schonmann, A.T. Campagnoni. Two neuronal cell lines expressing the myelin basic protein gene display differences in their in vitro survival and in their response to glia. Journal of neuroscience research, 1998 Nov 1;54(3):309-19.. DOI: doi.org/10.1002/(sici)1097-4547(19981101)54:3<309::aid-jnr2>3.0.co;2-5

R. Tikoo, D.J. Osterhout, P. Casaccia-Bonnefil, P. Seth, A. Koff, M.V. Chao. Ectopic expression of p27Kip1 in oligodendrocyte progenitor cells results in cell-cycle growth arrest. Journal of neurobiology, 1998 Sep 5;36(3):431-40.

S.O. Yoon, P. Casaccia-Bonnefil, B. Carter, M.V. Chao. Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998 May 1;18(9):3273-81.. DOI: doi.org/10.1523/jneurosci.18-09-03273.1998

M. Chao, P. Casaccia-Bonnefil, B. Carter, A. Chittka, H. Kong, S.O. Yoon. Neurotrophin receptors: mediators of life and death. Brain research. Brain research reviews, 1998 May;26(2-3):295-301.. DOI: doi.org/10.1016/s0165-0173(97)00036-2

P. Casaccia-Bonnefil, H. Kong, M.V. Chao. Neurotrophins: the biological paradox of survival factors eliciting apoptosis. Cell death and differentiation, 1998 May;5(5):357-64.. DOI: doi.org/10.1038/sj.cdd.4400377

P.J. Bergold, P. Casaccia-Bonnefil. Preparation of organotypic hippocampal slice cultures using the membrane filter method. Methods in molecular biology (Clifton, N.J.), 1997;72:15-22.. DOI: doi.org/10.1385/0-89603-394-5:15

P. Casaccia-Bonnefil, R. Tikoo, H. Kiyokawa, V.F. Jr, M.V. Chao, A. Koff. Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1. Genes & development, 1997 Sep 15;11(18):2335-46.. DOI: doi.org/10.1101/gad.11.18.2335

R. Tikoo, P. Casaccia-Bonnefil, M.V. Chao, A. Koff. Changes in cyclin-dependent kinase 2 and p27kip1 accompany glial cell differentiation of central glia-4 cells. The Journal of biological chemistry, 1997 Jan 3;272(1):442-7.. DOI: doi.org/10.1074/jbc.272.1.442

P. Casaccia-Bonnefil, B.D. Carter, R.T. Dobrowsky, M.V. Chao. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature, 1996 Oct 24;383(6602):716-9. DOI: doi.org/10.1038/383716a0

P. Casaccia-Bonnefil, L. Aibel, M.V. Chao. Central glial and neuronal populations display differential sensitivity to ceramide-dependent cell death. Journal of neuroscience research, 1996 Feb 1;43(3):382-9.. DOI: doi.org/10.1002/(sici)1097-4547(19960201)43:3<382::aid-jnr13>3.0.co;2-7

P. Casaccia-Bonnefil, A. Stelzer, H.J. Federoff, P.J. Bergold. A role for mossy fiber activation in the loss of CA3 and hilar neurons induced by transduction of the GluR6 kainate receptor subunit. Neuroscience letters, 1995 May 19;191(1-2):67-70.. DOI: doi.org/10.1016/0304-3940(95)11560-8

P. Casaccia-Bonnefil, E. Benedikz, H. Shen, A. Stelzer, D. Edelstein, M. Geschwind, M. Brownlee, H.J. Federoff, P.J. Bergold. Localized gene transfer into organotypic hippocampal slice cultures and acute hippocampal slices. Journal of neuroscience methods, 1993 Dec;50(3):341-51.. DOI: doi.org/10.1016/0165-0270(93)90040-x

E. Benedikz, P. Casaccia-Bonnefil, A. Stelzer, P.J. Bergold. Hyperexcitability and cell loss in kainate-treated hippocampal slice cultures. Neuroreport, 1993 Oct 25;5(1):90-2.. DOI: doi.org/10.1097/00001756-199310000-00025

P.J. Bergold, P. Casaccia-Bonnefil, X.L. Zeng, H.J. Federoff. Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor. Proceedings of the National Academy of Sciences of the United States of America, 1993 Jul 1;90(13):6165-9. DOI: doi.org/10.1073/pnas.90.13.6165

P. Casaccia-Bonnefil, E. Benedikz, R. Rai, P.J. Bergold. Excitatory and inhibitory pathways modulate kainate excitotoxicity in hippocampal slice cultures. Neuroscience letters, 1993 May 14;154(1-2):5-8.. DOI: doi.org/10.1016/0304-3940(93)90157-g

P. Casaccia-Bonnefil, R.J. Kascsak, R. Fersko, S. Callahan, R.I. Carp. Brain regional distribution of prion protein PrP27-30 in mice stereotaxically microinjected with different strains of scrapie. The Journal of infectious diseases, 1993 Jan;167(1):7-12.. DOI: doi.org/10.1093/infdis/167.1.7

A. Ladogana, P. Casaccia, L. Ingrosso, M. Cibati, M. Salvatore, Y.G. Xi, C. Masullo, M. Pocchiari. Sulphate polyanions prolong the incubation period of scrapie-infected hamsters. The Journal of general virology, 1992 Mar;73 ( Pt 3):661-5.. DOI: doi.org/10.1099/0022-1317-73-3-661

P. Casaccia, A. Ladogana, Y.G. Xi, L. Ingrosso, M. Pocchiari, M.C. Silvestrini, A. Cittadini. Measurement of the concentration of amphotericin B in brain tissue of scrapie-infected hamsters with a simple and sensitive method. Antimicrobial agents and chemotherapy, 1991 Jul;35(7):1486-8.. DOI: doi.org/10.1128/aac.35.7.1486

P. Casaccia, A. Ladogana, Y.G. Xi, M. Pocchiari. Levels of infectivity in the blood throughout the incubation period of hamsters peripherally injected with scrapie. Archives of virology, 1989;108(1-2):145-9.. DOI: doi.org/10.1007/bf01313752

M. Pocchiari, P. Casaccia, A. Ladogana. Amphotericin B: a novel class of antiscrapie drugs. The Journal of infectious diseases, 1989 Nov;160(5):795-802.. DOI: doi.org/10.1093/infdis/160.5.795

C. Masullo, M. Pocchiari, G. Neri, P. Casaccia, A. Iavarone, A. Ladogana, G. Macchi. A retrospective study of Creutzfeldt-Jakob disease in Italy (1972-1986). European journal of epidemiology, 1988 Dec;4(4):482-7.. DOI: doi.org/10.1007/bf00146403

R.G. Lim, O. Al-Dalahmah, J. Wu, M. P. Gold, J. C. Reidling, G. Tang, M. Adam, D. K. Dansu, H.-J. Park, P. Casaccia, R. Miramontes, A. M. Reyes-Ortiz, A. Lau, R. A. Hickman, F. Khan, F. Paryani, A. Tang, K. Ofori, E. Miyoshi, N. Michael, et al. Huntington Disease Oligodendrocyte Maturation Deficits Revealed by Single-Nucleus RNAseq Are Rescued by Thiamine-Biotin Supplementation. Nat Commun, 2022, 13 (1), 7791. DOI: https://doi.org/10.1038/s41467-022-35388-x.